Population distribution of the human vitamin D binding protein: Anthropological considerations
Identifieur interne : 000196 ( France/Analysis ); précédent : 000195; suivant : 000197Population distribution of the human vitamin D binding protein: Anthropological considerations
Auteurs : J. Constans [France] ; S. Hazout [France] ; R. M. Garruto ; D. C. Gajdusek ; E. K. Spees [États-Unis]Source :
- American Journal of Physical Anthropology [ 0002-9483 ] ; 1985-09.
English descriptors
Abstract
The polymorphism of the serum vitamin D binding protein (DBP) in humans is based on the existence of three common alleles, Gc1F, Gc1S, and Gc2, and 84 rare alleles. The geographical distribution of Gc1F, Gc1S, and Gc2 alleles shows north to south clines, together with a balanced equilibrium between the Gc1F or Gc1S allele frequency and the Gc2 frequency. The distribution of the FST values shows high variability within a geographical area. For European and North Asiatic groups, the FST values are the lowest observed, and the reason may be a long process of homogenization. Aboriginal populations from Australia and New Guinea and groups from both North Africa and South America show the greatest heterogeneity of their allele frequencies. Systematic factors such as genetic drift and selection may account for this distribution. In contrast with the three main DBP alleles, the distribution of the rare alleles corresponds to patterns of human migrations that occurred during prehistoric and historic periods. Thus, the rare mutants are of particular relevance to anthropological and genetical investigations.
Url:
DOI: 10.1002/ajpa.1330680110
Affiliations:
- France, États-Unis
- Maryland, Midi-Pyrénées, Occitanie (région administrative), Île-de-France
- Baltimore, Paris, Toulouse
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ISTEX:4C4A8299302A94C9D22C2942648C71CFB4B89F8CLe document en format XML
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Anthropol.</title><idno type="ISSN">0002-9483</idno><idno type="eISSN">1096-8644</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1985-09">1985-09</date><biblScope unit="volume">68</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="107">107</biblScope><biblScope unit="page" to="122">122</biblScope></imprint><idno type="ISSN">0002-9483</idno></series><idno type="istex">4C4A8299302A94C9D22C2942648C71CFB4B89F8C</idno><idno type="DOI">10.1002/ajpa.1330680110</idno><idno type="ArticleID">AJPA1330680110</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9483</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clusters</term><term>DBP subtypes</term><term>Heterogeneity</term><term>Migrations</term><term>Rare alleles</term><term>Worldwide distribution</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The polymorphism of the serum vitamin D binding protein (DBP) in humans is based on the existence of three common alleles, Gc1F, Gc1S, and Gc2, and 84 rare alleles. The geographical distribution of Gc1F, Gc1S, and Gc2 alleles shows north to south clines, together with a balanced equilibrium between the Gc1F or Gc1S allele frequency and the Gc2 frequency. The distribution of the FST values shows high variability within a geographical area. For European and North Asiatic groups, the FST values are the lowest observed, and the reason may be a long process of homogenization. Aboriginal populations from Australia and New Guinea and groups from both North Africa and South America show the greatest heterogeneity of their allele frequencies. Systematic factors such as genetic drift and selection may account for this distribution. In contrast with the three main DBP alleles, the distribution of the rare alleles corresponds to patterns of human migrations that occurred during prehistoric and historic periods. 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